(source: https://www.rsc.org/periodic-table/element/96/curium)

“Element 96” was synthesised by bombarding plutonium 239 with  alpha particles to produce curium242 and curium 240: Element 96 And Compositions Thereof (1964).

Later, other curium isotopes were synthesised:

Large scale production of curium was achieved by chemical processing of fission products: Large Scale Method For The Production And Purification Of Curium (1959).

One of the biggest challenges seems to be the separation of curium from americium (Separation Of Curium And Americium (1962)), and many patent applications have been filed for inventions addressing this problem.

Applications of curium include:

References:

All patent information has been obtained from Espacenet (European Patent Office).